The Natural Aging Process


Disc degeneration follows a predictable pattern: first, the disc experiences a decline in nutritional supply and cell function; second, the disc begins to lose its ability to absorb water and the fibers of the disc begin to be overloaded and to accumulate damage; third, this leads to a general loss of hydration with the nucleus (center of the disc) becoming more fibrous, so that it looks much the same as the annulus (outer region of the disc) which is simultaneously degrading in its mechanical strength, affecting the motion of the joint, with pain typically beginning at this stage; fourth, routine stress and strain can take a toll on the structures of the spine, tears can form in the annulus, damage can occur to the disc endplates, the disc can bulge, the inner part of the disc can be extruded into the spinal cord region, the disc can begin to collapse, the spinal facet joints can degrade, pain can become worse at this stage.


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Dr. Grider explains how GENTIS fills the treatment opportunity gap.

​​A Global Problem

About 80% of the adults in the U.S. and 50% of European adults will be bothered by degenerative disc associated low back pain at some point in their life, with lifetime recurrence rates up to 85 percent. 


In the United States, the estimated annual cost of back pain, including medical costs and lost productivity, is between $50 and $100 billion, with an estimated 10-12% of the population disabled by chronic low back pain

Due to the absence of effective pain and disability treatments that also resist the progression of the disorder, many of these chronic low back pain patients are ineffectively managed with conservative treatment approaches, including temporary pain reducing injections, until their condition gets worse, sometimes necessitating expensive surgical intervention.  Unfortunately, these extended conservative care and pain injection approaches do not typically get these patients back to work or limit their ongoing healthcare expenses.  Worse yet, opioids are often prescribed to deal with this chronic pain, contributing more than any other type of chronic pain to the current opioid crisis.

GENTIS (GEnipin Nano-Tether Injectable Stabilization) provides an opioid free, long-term, injectable, spine stabilizing solution for this widespread chronic pain problem.